CEFTAROLINE PACKAGE INSERT PDF

For Injection: Teflaro is supplied as mg or mg of sterile ceftaroline fosamil powder in single-dose, 20 mL clear glass. There is minimal potential for drug-drug interactions between TEFLARO and CYP substrates, inhibitors, or inducers; drugs known to undergo active renal . To reduce the development of drug-resistant bacteria and maintain the effectiveness of TEFLARO and other antibacterial drugs, TEFLARO should be used to.

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Zinforo 600 mg powder for concentrate for solution for infusion

Cellulitis For illustrative purposes only. CDAD and severe hypersensitivity reactions may also occur.

Marketing authorisation number s 9. In clinical studies there was no evidence of haemolysis in patients who developed a positive DAGT on treatment. Please confirm that you are a healthcare professional in the United States.

In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Streptococcus pneumoniae including cases with concurrent bacteremiaStaphylococcus aureus methicillin-susceptible isolates onlyHaemophilus influenzaeKlebsiella pneumoniaeKlebsiella oxytocaand Escherichia coli.

Accessed August 11, Patients with pre-existing seizure disorder Seizures have occurred in toxicology studies at times human ceftaroline C max levels see section 5. Zinforo is indicated for the treatment of the following infections in adults and children from the age of 2 months see sections 4. Mechanism of action In vitro studies have shown that ceftaroline is bactericidal and able to inhibit bacterial cell wall synthesis in methicillin-resistant Staphylococcus aureus MRSA and penicillin non-susceptible Streptococcus pneumoniae PNSP due to its affinity for the altered penicillin-binding proteins PBPs found in these organisms.

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Dosage and Administration Dosage and Administration Preparation of Solutions Dosing The minute infusion allows increased flexibility of infusion time See dosing. Table 5 Frequency of adverse reactions by system organ class from clinical trials and post-marketing experience System organ class Very common Common Uncommon Rare Not known Infections and infestations Clostridium difficile colitis see section 4.

Reasons for being admitted to the hospital through the emergency department, Clinical study experience with ceftaroline fosamil in patients with pre-existing seizure disorders is very limited.

Interaction with other antibacterial agents In vitro studies have not demonstrated any antagonism between ceftaroline in combination with other commonly used antibacterial agents e.

Overall, no adverse effects on fertility or post-natal ceftzroline were observed in the rat at up to 5 times the observed clinical exposure. Paediatric population As with adults, the interaction potential is expected to be low in paediatrics.

Arrived in ED with an abscess on packxge forearm that has worsened from a scrape. Diarrhoea, nausea, vomiting, abdominal pain. I prefer to be contacted by: Arrived in ED with an abscess with surrounding cellulitis on right thigh.

ABSSSI & CABP IV Therapy | TEFLARO® (ceftaroline fosamil)

Please confirm that you are a healthcare professional in the United States. Breast-feeding It is unknown whether ceftaroline fosamil or ceftaroline is excreted in human milk.

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To view the changes to a medicine you must sign up and log in. No clinical drug-drug interaction studies have been conducted with ceftaroline fosamil.

Weight-based dosing is required for pediatric patients. Ceftaroline is primarily eliminated by the kidneys. Name of the medicinal product 2.

Ceftaroline fosamil and ceftaroline were clastogenic in an in vitro chromosomal aberration assay, however there was no evidence of mutagenic activity in an Ames test, mouse lymphoma and unscheduled DNA synthesis ceftarpline. In vitro results do not necessarily correlate with how the antibiotic will work in people. Arrived in ED with an abscess due to a suspected spider bite on her left leg.

Refers to dosing of adults or adolescents from 12 years and 33 kg with ceftaroline every 12 hours using 1-hour infusions see section 4. Hypersensitivity to the active substance or to any of the excipients listed in section 6. Preferred Contact is required Phone. The kidney ceftarollne the primary target organ of toxicity in both the monkey and rat. Arrived in ED with leg wound.

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