Species affected: Mainly chickens, serotype 2 also occurs in turkeys and ducks. Age affected: Causes: Infectious bursal disease virus is a birnavirus. It is highly . Infectious bursal disease – Immunosuppression – Pathotype – Vaccination. Summary. Introduction in the sector over the sanitary status of poultry. Gumboro. In all poultry producing regions of the world, infectious bursal disease virus (IBDV ) continues to be a major constraint for poultry farmers.

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As this disease has been focused in recent reviews regarding its causative agent [ 17 ] and the vaccination [ 1819 ], the present study is, therefore, mainly inclined toward the timely and reliable diagnosis of this threatening disease using gross, histopathology HPimmunohistochemistry IHC piultry, and immunofluorescent methods.

Abstract Fulltext Metrics Get Permission. For IHC studies, section s were taken on poly-L-Lysine coated slide and then subjected to clearing and then rehydration. Infectious bursal disease Virus classification Group: As the viral capsid protein, VP2 carries immunodominant epitopes responsible for the induction of a protective humoral immune response. However, the B-cell destruction is usually most severe in subclinically infected young, as virus will destroy a smaller population and most cells in one place the bursa.

The affected bursal sections revealed viral antigens in the lesion sites identified in tissue sections, especially inside the cells in the rarefied areas of bursal follicles along with the inner lining of the cystic cavities in affected follicles. The potential for economic losses in the poultry industry also exists when anytime a new antigenic or pathogenic strain of IBDV is introduced into a country or geographic region [ 10 ].

Different domains of the RNA polymerase of infectious bursal disease virus contribute to virulence. Sequence comparisons of the variable VP2 region of eight infectious bursal disease virus isolates. Infectious bursal disease virus and proventriculitis in broiler chickens. In the similar way, the extent to which bursas got fibrosed was also highest in the fourth outbreak 2. This mean represented the overall damage to the histo-architecture, which was then compared with the IHC scoring of the 27 histopathologically positive samples out of 33 total samples using the Graphpad Prism software.


These slides were then washed in phosphate buffer saline for 20 min.

Infectious bursal disease

In premises, once contaminated with the IBD virus, the disease tends to recur, usually as subclinical infection. Can J Vet Res. The IBDV antigens were also localized in the respiratory ciliated epithelium Figure-8 at the affected sites in the proventricular sections and in the heart muscle Figure-9whereas Pantin-Jackwood and Brown [ 35 ] did not report any IBDV antigen gumbroo the proventriculus.

Acute disease and death is due to the necrotizing effect of these viruses on the host tissues. Pathogenicity of IBDV related to outbreaks in the vaccinated flocks diwease the causes of vaccination failure.

Subclinical disease occurs in chickens infected before three weeks of age. Collection and processing of samples A total of six poultry farms were visited in and around the areas of Ludhiana and the other districts of Punjab, as shown in Table It is concluded that the bursa is the main organ involved in the pathogenesis of IBD and thus also acts as an organ of ggumboro for demonstrating IBDV antigen for specific diagnosis of disease using IHC.

Infectious bursal diseaseIBD also known as Gumboro disease, infectious bursitis and infectious avian nephrosis is a highly contagious disease of young chickens caused by infectious bursal disease virus IBDV[1] characterized by immunosuppression and mortality generally at 3 to 6 weeks of age. Historically, IBDV evolution has three major events: Bursal transcriptome of chickens protected by DNA vaccination versus those challenged xisease infectious bursal disease virus.

All major poultry producing regions report the coexistence of two or more strains of variable pathogenicity.

Efficacy of a novel infectious bursal disease virus immune complex vaccine in broiler chickens. It is economically important to the poultry industry worldwide due to increased susceptibility to other diseases and negative interference with effective vaccination.

Significance of the genetic relationships deduced from partial nucleotide sequencing of infectious bursal disease virus genome segments Dusease or B.

[Full text] Infectious bursal disease virus in poultry: current status and future | VMRR

Protective immune responses of recombinant VP2 subunit antigen of infectious bursal disease virus in chickens. Significance of bursa of Fabricius as target organ in infectious bursal disease of chickens. Chicken heat shock protein 90 is a component of the putative cellular receptor complex of infectious bursal disease virus.


Received 11 September An overview of infectious bursal disease. Pathogenicity and immunosuppressive properties of GM strain of infectious bursal disease virus in commercial broiler chickens.

Published 19 January Volume The enhanced virulence of very virulent infectious bursal disease virus is partly determined by its B-segment.

Infectious bursal disease – Wikipedia

Acute infectious bursal disease in poultry: Infected macrophages transport the virus to the Dksease, where extensive replication takes place.

Differential modulation of cytokine, chemokine and Toll like receptor expression in chickens infected with classical and variant infectious bursal disease virus. Chicken bone marrow-derived dendritic cells maturation in response to infectious bursal disease virus. Therefore, IBDV isolates with different genotypic and phenotypic diversity exist.

The diagnosis of very virulent infectious bursal disease in California pullets. Expression and localization of IBD specific viral antigens were noticed mainly intracellular to the rarefied areas of bursal follicle section sin conjunction to inner lining of the cystic cavities of affected follicles. DNA vaccination with VP2 gene fragment confers protection against infectious bursal disease virus in chickens.

Clinical aspects of immunosuppression in poultry. In addition to this, the findings of the present study also coincided with the findings of Haghighi et al. Based on geographic origin, phylogenetic analysis using either partial or gkmboro VP2 nucleotide sequences clustered vvIBDV strains in one well-defined major monophyletic lineage.

Induction of protective immunity in chickens immunized with plant-made chimeric Bamboo mosaic virus particles expressing very virulent Infectious bursal disease virus antigen. DNA-mediated vaccination conferring protection against infectious bursal disease in broiler chickens in the presence of maternal antibody. Smith et al 62 demonstrated higher expression of NK lysin to approximately fold at 4 days post infection dpi compared with virus-free controls suggesting cytotoxic T-cells and NK pkultry involvement.

IBD could however be observed as long as chickens have a functioning bursa up to the diseqse of 16 weeks.

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